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Systemic complement activation in age-related macular degeneration.

Abstract:

Dysregulation of the alternative pathway (AP) of complement cascade has been implicated in the pathogenesis of age-related macular degeneration (AMD), the leading cause of blindness in the elderly. To further test the hypothesis that defective control of complement activation underlies AMD, parameters of complement activation in blood plasma were determined together with disease-associated genetic markers in AMD patients. Plasma concentrations of activation products C3d, Ba, C3a, C5a, SC5b-9,...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0002593

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Pro Retina Foundation Pro-Re/Seed/Issa.1 More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
3
Issue:
7
Article number:
e2593
Publication date:
2008-01-01
DOI:
EISSN:
1932-6203
Source identifiers:
101369
Language:
English
Keywords:
UUID:
uuid:02cb3c62-9cde-47a9-8525-04d21190d0c1
Local pid:
pubs:101369
Deposit date:
2012-12-19

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