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Journal article

Behavioural characterization of neuregulin 1 type I overexpressing transgenic mice.

Abstract:

Neuregulin 1 (NRG1) is a pleiotropic growth factor involved in diverse aspects of brain development and function. In schizophrenia, expression of the NRG1 type I isoform is selectively increased. However, virtually nothing is known about the roles of this isoform in brain. We have studied transgenic mice overexpressing type I NRG1(NRG1type 1-tg) using a series of behavioural tests. NRG1(type 1-tg) mice have a tremor, are impaired on the accelerating rotarod, and have reduced prepulse inhibiti...

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Publication status:
Published

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Journal:
Neuroreport
Volume:
20
Issue:
17
Pages:
1523-1528
Publication date:
2009-11-05
DOI:
EISSN:
1473-558X
ISSN:
0959-4965
URN:
uuid:02c20403-5c0b-49cf-ac27-c94abb4929c7
Source identifiers:
21541
Local pid:
pubs:21541

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