- Abstract:
-
Neuregulin 1 (NRG1) is a pleiotropic growth factor involved in diverse aspects of brain development and function. In schizophrenia, expression of the NRG1 type I isoform is selectively increased. However, virtually nothing is known about the roles of this isoform in brain. We have studied transgenic mice overexpressing type I NRG1(NRG1type 1-tg) using a series of behavioural tests. NRG1(type 1-tg) mice have a tremor, are impaired on the accelerating rotarod, and have reduced prepulse inhibiti...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1097/wnr.0b013e328330f6e7
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- Journal:
- Neuroreport
- Volume:
- 20
- Issue:
- 17
- Pages:
- 1523-1528
- Publication date:
- 2009-11-05
- DOI:
- EISSN:
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1473-558X
- ISSN:
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0959-4965
- URN:
-
uuid:02c20403-5c0b-49cf-ac27-c94abb4929c7
- Source identifiers:
-
21541
- Local pid:
- pubs:21541
- Copyright date:
- 2009
Journal article
Behavioural characterization of neuregulin 1 type I overexpressing transgenic mice.
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