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Distribution of functional HIV-specific CD8 T lymphocytes between blood and secondary lymphoid organs after 8-18 months of antiretroviral therapy in acutely infected patients.

Abstract:

OBJECTIVES: To assess whether drug-induced suppression of the plasma viral load is associated with selective differential distribution of virus-specific CD8 T cells between the blood and secondary lymphoid organs. METHODS: HIV-specific CD8 T lymphocyte responses were quantified in matched peripheral blood and lymph node samples from seven patients starting treatment shortly after infection, who received antiretroviral therapy (ART) for a median of 14 months. Cells recovered from samples were ...

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Publication status:
Published

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Authors


Oxenius, A More by this author
Ramirez, E More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Biomedical Research Centre
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Journal:
AIDS (London, England)
Volume:
15
Issue:
13
Pages:
1653-1656
Publication date:
2001-09-05
DOI:
EISSN:
1473-5571
ISSN:
0269-9370
URN:
uuid:02bb7952-7648-4d85-b866-22467bf7fdd6
Source identifiers:
10927
Local pid:
pubs:10927

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