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Prioritizing causal genes at type 2 diabetes risk loci

Abstract:

Purpose of review: Genome-wide association studies (GWAS) for type 2 diabetes (T2D) risk have identified a large number of genetic loci associated with disease susceptibility. However, progress moving from association signals through causal genes to functional understanding has so far been slow, hindering clinical translation. This review discusses the benefits and limitations of emerging, unbiased approaches for prioritizing causal genes at T2D risk loci. Recent findings: Candidate causal g...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/s11892-017-0907-y

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Oxford college:
St Cross College
Role:
Author
More from this funder
Funding agency for:
Grotz, A
Grant:
SeniorFellowinBasic BiomedicalScience(095101/Z/10/Z
200837/Z/16/Z
Publisher:
Springer US Publisher's website
Journal:
Current Diabetes Reports Journal website
Volume:
17
Issue:
9
Article number:
76
Publication date:
2017-07-31
Acceptance date:
2017-06-29
DOI:
EISSN:
1539-0829
ISSN:
1534-4827
Keywords:
Pubs id:
pubs:710160
UUID:
uuid:02b419f4-3b11-492e-ba82-59c9ab9c6f37
Local pid:
pubs:710160
Deposit date:
2017-08-02

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