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Autoimmune channelopathies: new antibody-mediated disorders of the central nervous system.

Abstract:

Contrary to established wisdom, there now appear to be antibody-mediated central nervous system (CNS) disorders. Over the last few years, a number of patients have been defined with antibodies to voltage-gated (VGKC) or ligand-gated (NMDAR, GlyR) ion channels or ungated water (AQP4) channels. Some of the disorders improve spontaneously over time, others may be more chronic and relapsing-remitting, but immunotherapies reduce antibody levels and improve clinical outcomes. These are exciting dev...

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Publisher copy:
10.3410/b1-61

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
Journal:
F1000 biology reports
Volume:
1
Pages:
61
Publication date:
2009-01-01
DOI:
EISSN:
1757-594X
URN:
uuid:02a8bc7e-5bab-4af5-b580-6d54cc412a57
Source identifiers:
242060
Local pid:
pubs:242060
Language:
English

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