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Antigen receptor engagement delivers a stop signal to migrating T lymphocytes.

Abstract:

We investigated the role of the T cell antigen receptor (TcR) in control of T cell migration in an in vitro system. We used T cells from transgenic mice bearing a TcR for the lysozyme peptide 48-62 bound to I-A(k) (3A9). T cells from the 3A9 TcR transgenic mice crawled on purified intercellular adhesion molecule-1 substrates, but strikingly, stopped upon interaction with the physiological ligand, i.e., the mouse I-A(k) with covalently attached hen egg white lysozyme peptide residues 48-62 com...

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Publisher copy:
10.1073/pnas.94.8.3909

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Bromley, SK More by this author
Peterson, DA More by this author
Unanue, ER More by this author
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
94
Issue:
8
Pages:
3909-3913
Publication date:
1997-04-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:02a1da19-2874-47b2-b5d9-32295d42e266
Source identifiers:
482678
Local pid:
pubs:482678

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