Conference item

Molecular mechanisms of Lck activity regulation in human peripheral blood T lymphocytes

Abstract:: Lck activation during T cell signaling is still not completely understood. In order to study this regulation in more physiologic stimulation conditions, we used resting human peripheral blood CD4(+) lymphoblasts stimulated with SAg-loaded APC's. Here we show that dephosphorylation of its negative regulatory residue (Tyr505) is a pre-requisite for promoting phosphorylation of Tyr394 residue in the kinase domain further enhancing the activity of Lek.

Publication status:: Published

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APA Style

Irles, C., Ortega, A., Michel, F., Acuto, O., & MEDIMOND. (2004). Molecular mechanisms of Lck activity regulation in human peripheral blood T lymphocytes. 12th Annual International Congress of Immunology and 4th Annual Conference of the Federation-of-Clinical-Immunology-Societies (FOCIS), 163–167.

MLA Style

Irles, C, et al. “Molecular Mechanisms of Lck Activity Regulation in Human Peripheral Blood T Lymphocytes.” 12th Annual International Congress of Immunology and 4th Annual Conference of the Federation-of-Clinical-Immunology-Societies (FOCIS), 2004, pp. 163–67.

Chicago Style

Irles, C, A Ortega, F Michel, O Acuto, and MEDIMOND. 2004. “Molecular Mechanisms of Lck Activity Regulation in Human Peripheral Blood T Lymphocytes.” In 12th Annual International Congress of Immunology and 4th Annual Conference of the Federation-of-Clinical-Immunology-Societies (FOCIS), 163–67.
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Authors

+ Irles, C More by this author

Role:: Author

+ Ortega, A More by this author

Role:: Author

+ Michel, F More by this author

Role:: Author

+ Acuto, O More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Pathology Dunn School
Role:: Author

+ MEDIMOND More by this author

Role:: Author

Journal:: IMMUNOLOGY 2004: CYTOKINE NETWORK, REGULATORY CELLS, SIGNALING, AND APOPTOSIS More from this journal
Pages:: 163-167
Publication date:: 2004-01-01
Event title:: 12th Annual International Congress of Immunology and 4th Annual Conference of the Federation-of-Clinical-Immunology-Societies (FOCIS)
ISBN:: 8875870691

Keywords:: PROTEIN-TYROSINE KINASE

FYN

CSK

ENRICHED MICRODOMAINS

lipid rafts

CELL-ACTIVATION
Pubs id:: pubs:9541
UUID:: uuid:0297dcae-c64b-47b3-abff-97408bc8b3cb
Local pid:: pubs:9541
Source identifiers:: 9541
Deposit date:: 2012-12-19
ARK identifier:: ark:/29072/ora_0297dcaec64b47b3abff97408bc8b3cb

Terms of use

Copyright date:: 2004

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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