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A free-running DNA motor powered by a nicking enzyme.

Abstract:
(Figure Presented) DNA burns its bridges: A unidirectional molecular motor that moves an oligonucleotide cargo along a self-assembled track is powered by restriction endonuclease hydrolysis of the phosphodiester backbone (see scheme). Damage caused to the track by the restriction enzyme prevents the cargo from stepping backwards and therefore imposes directionality. © 2005 Wiley-VCH Verlag GmbH and Co. KGaA.
Publication status:
Published

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Publisher copy:
10.1002/anie.200501262

Authors

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Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Sub department:
Condensed Matter Physics
Role:
Author


Journal:
Angewandte Chemie (International ed. in English) More from this journal
Volume:
44
Issue:
28
Pages:
4358-4361
Publication date:
2005-07-01
DOI:
EISSN:
1521-3773
ISSN:
1433-7851


Language:
English
Keywords:
Pubs id:
pubs:9214
UUID:
uuid:029133fa-58b3-4ebc-a01a-9c79e3af4949
Local pid:
pubs:9214
Source identifiers:
9214
Deposit date:
2012-12-19
ARK identifier:

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