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HLA-A*7401-mediated control of HIV viremia is independent of its linkage disequilibrium with HLA-B*5703.

Abstract:

The potential contribution of HLA-A alleles to viremic control in chronic HIV type 1 (HIV-1) infection has been relatively understudied compared with HLA-B. In these studies, we show that HLA-A*7401 is associated with favorable viremic control in extended southern African cohorts of >2100 C-clade-infected subjects. We present evidence that HLA-A*7401 operates an effect that is independent of HLA-B*5703, with which it is in linkage disequilibrium in some populations, to mediate lowered vire...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.1003711

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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
186
Issue:
10
Pages:
5675-5686
Publication date:
2011-05-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:028fb0a9-3ecd-4286-8123-19416d0d8cf4
Source identifiers:
134952
Local pid:
pubs:134952

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