Journal article icon

Journal article

Radiation sensitization by inhibition of activated Ras.

Abstract:

BACKGROUND AND PURPOSE: Ras has been identified as a significant contributor to radiation resistance. This article reviews preclinical and phase I clinical studies that reported on combining inhibition of activated Ras and downstream effectors of Ras with radiotherapy. MATERIAL AND METHODS: Transfection studies and RNA interference were used to check the role of the Ras isoforms for intrinsic radiation sensibility. Western blotting was used to control for prenylation inhibition of the respec...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1007/s00066-004-9198-8

Authors


Brunner, TB More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Bernhard, EJ More by this author
Journal:
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]
Volume:
180
Issue:
11
Pages:
731-740
Publication date:
2004-11-05
DOI:
EISSN:
1439-099X
ISSN:
0179-7158
URN:
uuid:028dc7b3-9fd3-45e6-a017-1ad4b1ec2c89
Source identifiers:
118205
Local pid:
pubs:118205

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP