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Journal article

The GPS motif is a molecular switch for bimodal activities of adhesion class G protein-coupled receptors.

Abstract:

Adhesion class G protein-coupled receptors (aGPCR) form the second largest group of seven-transmembrane-spanning (7TM) receptors whose molecular layout and function differ from canonical 7TM receptors. Despite their essential roles in immunity, tumorigenesis, and development, the mechanisms of aGPCR activation and signal transduction have remained obscure to date. Here, we use a transgenic assay to define the protein domains required in vivo for the activity of the prototypical aGPCR LAT-1/La...

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Publication status:
Published

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Journal:
Cell reports
Volume:
2
Issue:
2
Pages:
321-331
Publication date:
2012-08-01
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
Source identifiers:
348892
Language:
English
Keywords:
Pubs id:
pubs:348892
UUID:
uuid:028c30f4-42de-49ad-a6d0-fdabdb53886d
Local pid:
pubs:348892
Deposit date:
2013-11-16

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