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Prenatal and postnatal myeloid cells demonstrate stepwise progression in the pathogenesis of MLL fusion gene leukemia.

Abstract:

The steps to leukemia following an in utero fusion of MLL (HRX, ALL-1) to a partner gene in humans are not known. Introduction of the Mll-AF9 fusion gene into embryonic stem cells results in leukemia in mice with cell-type specificity similar to humans. In this study we used myeloid colony assays, immunophenotyping, and transplantation to evaluate myelopoiesis in Mll-AF9 mice. Colony assays demonstrated that both prenatal and postnatal Mll-AF9 tissues have significantly increased numbers of C...

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Publisher copy:
10.1182/blood-2002-05-1515

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Journal:
Blood
Volume:
101
Issue:
8
Pages:
3229-3235
Publication date:
2003-04-01
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
Source identifiers:
324284

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