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CRISPR-based adaptive and heritable immunity in prokaryotes.

Abstract:

The recently discovered CRISPR (clustered regularly interspaced short palindromic repeat) defense system protects bacteria and archaea against mobile genetic elements. This immunity system has the potential to continuously adjust its reach at the genomic level, implying that both gain and loss of information is inheritable. The CRISPR system consists of typical stretches of interspaced repetitive DNA (CRISPRs) and associated cas genes. Three distinct stages are recognized in the CRISPR defens...

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Publisher copy:
10.1016/j.tibs.2009.05.002

Authors


van der Oost, J More by this author
Westra, ER More by this author
Lundgren, M More by this author
Brouns, SJ More by this author
Journal:
Trends in biochemical sciences
Volume:
34
Issue:
8
Pages:
401-407
Publication date:
2009-08-05
DOI:
ISSN:
0968-0004
URN:
uuid:026fc75b-ae9d-4d12-a864-27bdc973a150
Source identifiers:
382769
Local pid:
pubs:382769

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