Journal article
Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants
- Abstract:
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The discovery of genetic loci associated with complex diseases has outpaced the elucidation of mechanisms of disease pathogenesis. Here we conducted a genome-wide association study (GWAS) for coronary artery disease (CAD) comprising 181,522 cases among 1,165,690 participants of predominantly European ancestry. We detected 241 associations, including 30 new loci. Cross-ancestry meta-analysis with a Japanese GWAS yielded 38 additional new loci. We prioritized likely causal variants using functi...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 7.0MB, Terms of use)
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- Publisher copy:
- 10.1038/s41588-022-01233-6
Bibliographic Details
- Publisher:
- Springer Nature
- Journal:
- Nature Genetics More from this journal
- Volume:
- 54
- Issue:
- 12
- Pages:
- 1803-1815
- Publication date:
- 2022-12-06
- Acceptance date:
- 2022-10-17
- DOI:
- EISSN:
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1546-1718
- ISSN:
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1061-4036
- Pmid:
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36474045
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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1312193
- Local pid:
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pubs:1312193
- Deposit date:
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2023-02-23
Terms of use
- Copyright holder:
- Aragam et al.
- Copyright date:
- 2022
- Rights statement:
- Copyright © 2022, The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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