Journal article

A route to the thapsigargins from (S)-carvone providing a substrate-controlled total synthesis of trilobolide, nortrilobolide, and thapsivillosin F.

Abstract:: An entirely substrate-controlled total synthesis of three members of the thapsigargin family (e.g. trilobolide) is achieved starting from (S)-carvone. The synthesis is linear in nature but is achieved in high yield (> 90% per step). The route permits late-stage divergence, providing access to a range of natural products and structural analogues.

Publication status:: Published

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APA Style

Oliver, S., Högenauer, K., Simic, O., Antonello, A., Smith, M., & Ley, S. (2003). A route to the thapsigargins from (S)-carvone providing a substrate-controlled total synthesis of trilobolide, nortrilobolide, and thapsivillosin F. Angewandte Chemie (International Ed. in English), 42(48), 5996–6000.

MLA Style

Oliver, S, et al. “A Route to the Thapsigargins from (S)-Carvone Providing a Substrate-Controlled Total Synthesis of Trilobolide, Nortrilobolide, and Thapsivillosin F.” Angewandte Chemie (International Ed. in English), vol. 42, no. 48, 2003, pp. 5996–6000.

Chicago Style

Oliver, S, K Högenauer, O Simic, A Antonello, M Smith, and S Ley. 2003. “A Route to the Thapsigargins from (S)-Carvone Providing a Substrate-Controlled Total Synthesis of Trilobolide, Nortrilobolide, and Thapsivillosin F.” Angewandte Chemie (International Ed. in English) 42 (48): 5996–6000.
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Publisher copy:: 10.1002/anie.200353140

Authors

+ Oliver, S More by this author

Role:: Author

+ Högenauer, K More by this author

Role:: Author

+ Simic, O More by this author

Role:: Author

+ Antonello, A More by this author

Role:: Author

+ Smith, M More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Organic Chemistry
Role:: Author

More authors...

Journal:: Angewandte Chemie (International ed. in English) More from this journal
Volume:: 42
Issue:: 48
Pages:: 5996-6000
Publication date:: 2003-12-01
DOI:: 10.1002/anie.200353140
EISSN:: 1521-3773
ISSN:: 1433-7851

Language:: English
Keywords:: Azulenes

Monoterpenes

Terpenes

Butyrates

Furans

Sesquiterpenes

Sesquiterpenes, Guaiane
Pubs id:: pubs:58770
UUID:: uuid:026a834b-dc4b-4b9b-a111-88058b4ebaaa
Local pid:: pubs:58770
Source identifiers:: 58770
Deposit date:: 2012-12-19
ARK identifier:: ark:/29072/ora_026a834bdc4b4b9ba11188058b4ebaaa

Terms of use

Copyright date:: 2003

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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