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Cerebral blood flow alteration in neuroprotection following cerebral ischaemia.

Abstract:

The best neuroprotectant for acute ischaemic stroke would always be the rapid return of oxygen and glucose to physiological levels. This is currently provided by thrombolysis which restores blood flow to the ischaemic region. The attempt to confer neuroprotection by targeting the brain parenchyma has shown promise in experimental stroke models, but has unequivocally failed to translate to the clinic. Neuroprotective therapy primarily targets the biochemical cascade that produces cell death fo...

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Institution:
University of Oxford
Department:
Oxford
More by this author
Institution:
University of Oxford
Department:
Oxford
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Stroke and Geratology
Journal:
The Journal of physiology
Volume:
589
Issue:
Pt 17
Pages:
4105-4114
Publication date:
2011-09-05
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
URN:
uuid:0268489f-f6d3-4f5a-b134-52499263f741
Source identifiers:
163938
Local pid:
pubs:163938
Language:
English

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