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Increasing the dose intensity of chemotherapy by more frequent administration or sequential scheduling: a patient-level meta-analysis of 37 298 women with early breast cancer in 26 randomised trials

Abstract:

Background Increasing the dose intensity of cytotoxic therapy by shortening the intervals between cycles, or by giving individual drugs sequentially at full dose rather than in lower-dose concurrent treatment schedules, might enhance efficacy.

Methods To clarify the relative benefits and risks of dose-intense and standard-schedule chemotherapy in early breast cancer, we did an individual patient-level meta-analysis of trials comparing 2-weekly versu...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/S0140-6736(18)33137-4

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Dept of Population Health
Subgroup:
Clinical Trial Service Unit
ORCID:
0000-0003-4440-574X
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Dept of Population Health
Subgroup:
Clinical Trial Service Unit
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Dept of Population Health
Subgroup:
Clinical Trial Service Unit
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Dept of Population Health
Subgroup:
Clinical Trial Service Unit
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Dept of Population Health
Subgroup:
Clinical Trial Service Unit
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Cancer Research UK More from this funder
British Heart Foundation More from this funder
Medical Research Council More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Lancet Journal website
Volume:
393
Issue:
10179
Pages:
1440-1452
Publication date:
2019-02-08
Acceptance date:
2018-11-29
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
Pubs id:
pubs:950553
URN:
uri:025bed29-6fbe-48a2-a595-8e9843397c30
UUID:
uuid:025bed29-6fbe-48a2-a595-8e9843397c30
Local pid:
pubs:950553

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