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Journal article

Variable var transition rates underlie antigenic variation in malaria.

Abstract:

Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is expressed on the surface of infected erythrocytes where it plays a central role in both infected erythrocytes cytoadhesion and immune evasion. Switches in clonal expression of PfEMP1 result in antigenic variation that facilitates long-term chronic infection of the host. The var gene family encodes PfEMP1 variants, with transcriptional switching between different var variants providing the molecular basis for antigenic variation....

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0402347101

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
Role:
Author
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
101
Issue:
30
Pages:
11129-11134
Publication date:
2004-07-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:025ba205-5a97-4ba2-a34b-9cc71b8d66cc
Source identifiers:
18156
Local pid:
pubs:18156

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