Journal article
Use cases, best practice and reporting standards for metabolomics in regulatory toxicology
- Abstract:
- Metabolomics is a widely used technology in academic research, yet its application to regulatory science has been limited. The most commonly cited barrier to its translation is lack of performance and reporting standards. The Metabolomics standaRds Initiative in Toxicology (MERIT) project brings together international experts from multiple sectors to address this need. Here, we identify the most relevant applications for metabolomics in regulatory toxicology and develop best practice guidelines, performance and reporting standards for acquiring and analysing untargeted metabolomics and targeted metabolite data. We recommend that these guidelines are evaluated and implemented for several regulatory use cases.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 743.7KB, Terms of use)
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- Publisher copy:
- 10.1038/s41467-019-10900-y
Authors
- Publisher:
- Nature
- Journal:
- Nature Communications More from this journal
- Volume:
- 10
- Issue:
- 1
- Publication date:
- 2019-07-10
- Acceptance date:
- 2019-06-07
- DOI:
- ISSN:
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2041-1723
- Language:
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English
- Keywords:
- Pubs id:
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pubs:1032343
- UUID:
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uuid:025995ba-523f-4b84-9d10-f3859db00dbe
- Local pid:
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pubs:1032343
- Source identifiers:
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1032343
- Deposit date:
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2019-07-16
Terms of use
- Copyright holder:
- Viant et al
- Copyright date:
- 2019
- Notes:
- © Author(s) 2019. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
- Licence:
- CC Attribution (CC BY)
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