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Multistage multiantigen heterologous prime boost vaccine for Plasmodium knowlesi malaria provides partial protection in rhesus macaques.

Abstract:

A nonhuman primate model for malaria vaccine development allowing reliable, stringent sporozoite challenge and evaluation of both cellular and antibody responses is needed. We therefore constructed a multicomponent, multistage DNA vaccine for the simian malaria species Plasmodium knowlesi including two preerythrocytic-stage antigens, the circumsporozoite protein (PkCSP) and sporozoite surface protein 2 (PkSSP2), and two blood stage antigens, apical merozoite antigen 1 (PkAMA1) and merozoite s...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Role:
Author
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Journal:
Infection and immunity
Volume:
69
Issue:
9
Pages:
5565-5572
Publication date:
2001-09-05
DOI:
EISSN:
1098-5522
ISSN:
0019-9567
URN:
uuid:024a0487-2566-48e8-b262-a9624ba00451
Source identifiers:
81673
Local pid:
pubs:81673

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