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Global accumulation of circRNAs during aging in Caenorhabditis elegans

Abstract:
Background Circular RNAs (CircRNAs) are a newly appreciated class of RNAs that lack free 5′ and 3′ ends, are expressed by the thousands in diverse forms of life, and are mostly of enigmatic function. Ostensibly due to their resistance to exonucleases, circRNAs are known to be exceptionally stable. Previous work in Drosophila and mice have shown that circRNAs increase during aging in neural tissues. Results Here, we examined the global profile of circRNAs in ... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s12864-017-4386-y

Authors


Cortés-López, M More by this author
Gruner, MR More by this author
Cooper, DA More by this author
Gruner, HN More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Subgroup:
KIR
Oxford college:
St Edmund Hall
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Publisher:
BioMed Central Publisher's website
Journal:
BMC Genomics Journal website
Volume:
19
Pages:
Article: 8
Publication date:
2018-01-03
Acceptance date:
2017-12-15
DOI:
ISSN:
1471-2164
Pubs id:
pubs:952379
URN:
uri:0248b5dc-ddfd-4d74-ad78-ac898f87734d
UUID:
uuid:0248b5dc-ddfd-4d74-ad78-ac898f87734d
Local pid:
pubs:952379

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