Journal article

11β-Hydroxysteroid dehydrogenase type 1 as a therapeutic target in the metabolic syndrome

Abstract:: The global epidemic of obesity and the metabolic syndrome has focused the need for novel treatments. Here we describe the putative pathogenic role of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), an enzyme that generates active glucocorticoid, cortisol, within liver and adipose tissue. Furthermore, we review the published literature on the development of selective 11β-HSD1 inhibitors as a therapeutic strategy in light of their emerging role as insulin sensitisers. © 2005 Elsevier Ltd. All rights reserved.

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APA Style

Tomlinson, J., & Stewart, P. (2005). 11β-Hydroxysteroid dehydrogenase type 1 as a therapeutic target in the metabolic syndrome. Drug Discovery Today: Therapeutic Strategies, 2(2), 93–96.

MLA Style

Tomlinson, J, and P Stewart. “11β-Hydroxysteroid Dehydrogenase Type 1 as a Therapeutic Target in the Metabolic Syndrome.” Drug Discovery Today: Therapeutic Strategies, vol. 2, no. 2, 2005, pp. 93–96.

Chicago Style

Tomlinson, J, and P Stewart. 2005. “11β-Hydroxysteroid Dehydrogenase Type 1 as a Therapeutic Target in the Metabolic Syndrome.” Drug Discovery Today: Therapeutic Strategies 2 (2): 93–96.
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Publisher copy:: 10.1016/j.ddstr.2005.05.006

Authors

+ Tomlinson, J More by this author

Role:: Author

+ Stewart, P More by this author

Role:: Author

Journal:: Drug Discovery Today: Therapeutic Strategies More from this journal
Volume:: 2
Issue:: 2
Pages:: 93-96
Publication date:: 2005-01-01
DOI:: 10.1016/j.ddstr.2005.05.006
ISSN:: 1740-6773

Language:: English
Pubs id:: pubs:482142
UUID:: uuid:02478362-4e41-4093-9e54-29913d26482e
Local pid:: pubs:482142
Source identifiers:: 482142
Deposit date:: 2014-08-29
ARK identifier:: ark:/29072/ora_024783624e4140939e5429913d26482e

Terms of use

Copyright date:: 2005

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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