Journal article icon

Journal article

Adenosine release during seizures attenuates GABAA receptor-mediated depolarization.

Abstract:

Seizure-induced release of the neuromodulator adenosine is a potent endogenous anticonvulsant mechanism, which limits the extension of seizures and mediates seizure arrest. For this reason several adenosine-based therapies for epilepsy are currently under development. However, it is not known how adenosine modulates GABAergic transmission in the context of seizure activity. This may be particularly relevant as strong activation of GABAergic inputs during epileptiform activity can switch GABA(...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
Journal:
The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume:
32
Issue:
15
Pages:
5321-5332
Publication date:
2012-04-05
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
URN:
uuid:02474be8-caa4-4a18-a064-05da3035d07a
Source identifiers:
323064
Local pid:
pubs:323064

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP