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Evolutionary genetics: what is driving male mutation?

Abstract:
In mammals, most new mutations occur in males. But a study of the evolution of a human X to Y chromosomal translocation has revealed a sex bias much lower than previous estimates. Patterns of substitution suggest that differential methylation between male and female germ lines is a key determinant of the mutation rate.
Publication status:
Published

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Journal:
Current biology : CB
Volume:
10
Issue:
22
Pages:
R834-R835
Publication date:
2000-11-05
DOI:
EISSN:
1879-0445
ISSN:
0960-9822
URN:
uuid:024157b7-3bce-4a54-9509-c99bd8934f20
Source identifiers:
103155
Local pid:
pubs:103155

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