Evolutionary genetics: what is driving male mutation?

Journal article

In mammals, most new mutations occur in males. But a study of the evolution of a human X to Y chromosomal translocation has revealed a sex bias much lower than previous estimates. Patterns of substitution suggest that differential methylation between male and female germ lines is a key determinant of the mutation rate.

Authors: McVean, G

• Publication status: Published
• Journal: Current biology : CB
• Volume: 10
• Issue: 22
• Pages: R834-R835
• Publication date: 2000-11-01
• DOI: 10.1016/s0960-9822(00)00787-9
• EISSN: 1879-0445
• ISSN: 0960-9822
• Language: English
• Keywords: Animals; CpG Islands; Y Chromosome; Translocation, Genetic; Male; Sexual Maturation; Evolution, Molecular; X Chromosome; Female; DNA Methylation; Humans