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Active RNA polymerases: mobile or immobile molecular machines?

Abstract:

It is widely assumed that active RNA polymerases track along their templates to produce a transcript. We test this using chromosome conformation capture and human genes switched on rapidly and synchronously by tumour necrosis factor alpha (TNFalpha); one is 221 kbp SAMD4A, which a polymerase takes more than 1 h to transcribe. Ten minutes after stimulation, the SAMD4A promoter comes together with other TNFalpha-responsive promoters. Subsequently, these contacts are lost as new downstream ones ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
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Journal:
PLoS biology
Volume:
8
Issue:
7
Pages:
e1000419
Publication date:
2010
DOI:
EISSN:
1545-7885
ISSN:
1544-9173
URN:
uuid:023d4294-bc9a-484a-9d3f-733e014a9f7d
Source identifiers:
65905
Local pid:
pubs:65905

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