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Beyond 'furballs' and 'dumpling soups' - Towards a molecular architecture of signaling complexes and networks

Abstract:

The molecular architectures of intracellular signaling networks are largely unknown. Understanding their design principles and mechanisms of processing information is essential to grasp the molecular basis of virtually all biological processes. This is particularly challenging for human pathologies like cancers, as essentially each tumor is a unique disease with vastly deranged signaling networks. However, even in normal cells we know almost nothing. A few 'signalosomes', like the COP9 and th...

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Journal:
FEBS Letters
Volume:
586
Issue:
17
Pages:
2740-2750
Publication date:
2012-08-14
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
URN:
uuid:023bae58-2e04-4c12-9c9e-412ac701db9b
Source identifiers:
348970
Local pid:
pubs:348970

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