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The effect of genome-wide association scan quality control on imputation outcome for common variants.

Abstract:

Imputation is an extremely valuable tool in conducting and synthesising genome-wide association studies (GWASs). Directly typed SNP quality control (QC) is thought to affect imputation quality. It is, therefore, common practise to use quality-controlled (QCed) data as an input for imputing genotypes. This study aims to determine the effect of commonly applied QC steps on imputation outcomes. We performed several iterations of imputing SNPs across chromosome 22 in a dataset consisting of 3177 ...

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Publication status:
Published

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Publisher copy:
10.1038/ejhg.2010.242

Authors


Southam, L More by this author
Panoutsopoulou, K More by this author
Rayner, NW More by this author
Chapman, K More by this author
Durrant, C More by this author
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Journal:
European journal of human genetics : EJHG
Volume:
19
Issue:
5
Pages:
610-614
Publication date:
2011-05-05
DOI:
EISSN:
1476-5438
ISSN:
1018-4813
URN:
uuid:022d0a5a-b330-435d-8dd6-b1c67ad9e208
Source identifiers:
149850
Local pid:
pubs:149850

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