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A tractography analysis of two deep brain stimulation white matter targets for depression.

Abstract:

BACKGROUND: Deep brain stimulation (DBS) of the subcallosal cingulate white matter (SCCwm) or anterior limb of the internal capsule (ALIC) may be effective in treating depression. Connectivity patterns of these regions may inform on mechanisms of action for DBS of these targets. METHODS: Diffusion tensor imaging (DTI) and probabilistic tractography were performed in 13 nondepressed subjects to determine connectivity patterns of SCCwm and ALIC. Tract maps were generated for each target in each...

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Publication status:
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Authors


Gutman, DA More by this author
Holtzheimer, PE More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience, Experimental Psychology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Mayberg, HS More by this author
Journal:
Biological psychiatry
Volume:
65
Issue:
4
Pages:
276-282
Publication date:
2009-02-05
DOI:
EISSN:
1873-2402
ISSN:
0006-3223
URN:
uuid:022bc21b-97f4-45f6-a1e1-353e8e03dab6
Source identifiers:
4480
Local pid:
pubs:4480

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