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Identification of novel molecular scaffolds for the design of MMP-13 inhibitors: a first round of lead optimization.

Abstract:

Osteoarthritis (OA) is the leading cause of joint pain and disability in middle-aged and elderly patients, and is characterized by progressive loss of articular cartilage. Among the various matrix metalloproteinases (MMPs), MMP-13 is specifically expressed in the cartilage of human OA patients and is not present in normal adult cartilage. Thus, MMP-13-selective inhibitors are promising candidates in osteoarthritis therapy. Recently, we designed an N-isopropoxy-arylsulfonamide-based hydroxamat...

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Journal:
European journal of medicinal chemistry
Volume:
47
Issue:
1
Pages:
143-152
Publication date:
2012-01-05
DOI:
EISSN:
1768-3254
ISSN:
0223-5234
URN:
uuid:022714a3-f91d-401b-aed5-1fe10d8dbf7a
Source identifiers:
226561
Local pid:
pubs:226561

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