The postacrosomal assembly of sperm head protein, PAWP, is independent of acrosome formation and dependent on microtubular manchette transport.

Journal article

PAWP (postacrosomal sheath WW domain-binding protein) exclusively resides in the postacrosomal sheath (PAS) of the sperm perinuclear theca (PT). Because of the importance of this region in initiating oocyte activation during mammalian fertilization [Sutovsky, P., Manandhar, G., Wu, A., Oko, R., 2003. Interactions of sperm perinuclear theca with the oocyte: implications for oocyte activation, anti-polyspermy defense, and assisted reproduction. Microsc. Res. Tech. 61, 362-378; Wu, A., Sutovsky,...

Expand abstract

Authors: Wu, A; Sutovsky, P; Xu, W; van der Spoel, A; Platt, F

• Publication status: Published
• Journal: Developmental biology
• Volume: 312
• Issue: 2
• Pages: 471-483
• Publication date: 2007-12-01
• DOI: 10.1016/j.ydbio.2007.08.051
• EISSN: 1095-564X
• ISSN: 0012-1606
• Language: English
• Keywords: Mice, Inbred C57BL; Spermatozoa; Male; Testis; Tubulin; Acrosome; Fluorescent Antibody Technique; Animals; Microtubules; Mice; Biological Transport; Carrier Proteins; Seminal Plasma Proteins; Spermatogenesis