Role of thymidine phosphorylase in an in vitro model of human bladder cancer invasion.

Journal article

PURPOSE: It has been previously demonstrated that the angiogenic factor thymidine phosphorylase is elevated significantly in invasive bladder cancer. We report that it is not merely an incidental finding. Thymidine phosphorylase has a functional role in bladder cancer invasion. MATERIALS AND METHODS: The superficial bladder cancer cell line RT112 was transfected by retroviral techniques to generate the RT112-TP clone that expressed significantly elevated levels of thymidine phosphorylase, co...

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Authors: Jones, A; Fujiyama, C; Turner, K; Cranston, D; Williams, K

• Publication status: Published
• Journal: Journal of urology
• Volume: 167
• Issue: 3
• Pages: 1482-1486
• Publication date: 2002-03-01
• DOI: 10.1097/00005392-200203000-00084
• EISSN: 1527-3792
• ISSN: 0022-5347
• Language: English
• Keywords: Humans; Tumor Cells, Cultured; Thymidine Phosphorylase; Rats; Carcinoma, Transitional Cell; Prodrugs; Neoplasm Invasiveness; Mice; Animals; Mice, Nude; Disease Models, Animal; Urinary Bladder Neoplasms; Transfection