Manipulation of indoleamine 2,3-dioxygenase (IDO) for clinical transplantation: promises and challenges.

Journal article

BACKGROUND: Since the discovery that indoleamine 2,3-dioxygenase (IDO) is a modulator for maintenance of fetomaternal immuno-privilege state, it has been implicated in tumour tolerance, autoimmune diseases and asthma. IDO is an IFN-gamma-inducible, intracellular enzyme that catalyzes the initial and rate-limiting step in the degradation of tryptophan. It has been suggested that IDO can regulate the immune system either through deprivation of tryptophan that is essential for T cell proliferat...

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Authors: Quan, J; Tan, P; MacDonald, A; Friend, P

• Journal: Expert opinion on biological therapy
• Volume: 8
• Issue: 11
• Pages: 1705-1719
• Publication date: 2008-11-01
• DOI: 10.1517/14712598.8.11.1705
• EISSN: 1744-7682
• ISSN: 1471-2598
• Language: English
• Keywords: Interferon-gamma; Th2 Cells; Humans; Immunosuppressive Agents; Cell Survival; Organ Transplantation; Catalysis; Immune System; Indoleamine-Pyrrole 2,3,-Dioxygenase; Tryptophan; Genetic Vectors; T-Lymphocytes; Genetic Therapy; Protein Denaturation; Animals