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Interaction between prostaglandin D and chemoattractant receptor-homologous molecule expressed on Th2 cells mediates cytokine production by Th2 lymphocytes in response to activated mast cells.

Abstract:

The mechanisms by which immunologically activated mast cells stimulate the production of proinflammatory cytokines by T helper type 2 (Th2) lymphocytes were investigated in a human cell culture system. Supernatants collected from cord blood-derived mast cells after treatment with immunoglobulin E (IgE)/anti-IgE contained an activity that stimulated the production of interleukin (IL)-4, IL-5 and IL-13 (both mRNA and protein) by Th2 lymphocytes. This activity was not detected in supernatants fr...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Role:
Author
Journal:
Clinical and experimental immunology
Volume:
156
Issue:
1
Pages:
126-133
Publication date:
2009-04-05
DOI:
EISSN:
1365-2249
ISSN:
0009-9104
URN:
uuid:0215da34-f8b4-4335-ac85-7e047db8f68e
Source identifiers:
111099
Local pid:
pubs:111099

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