Hypoperfusion Precedes Tau Deposition in the Entorhinal Cortex: A Retrospective Evaluation of ADNI-2 Data

Journal article

BACKGROUND AND PURPOSE: Tau deposition in the entorhinal cortex is the earliest pathological feature of Alzheimer's disease (AD). However, this feature has also been observed in cognitively normal (CN) individuals and those with mild cognitive impairment (MCI). The precise pathophysiology for the development of tau deposition remains unclear. We hypothesized that reduced cerebral perfusion is associated with the development of tau deposition. METHODS: <0.05 indicating significance. RESULTS: =0.015, R²=0.11). CONCLUSIONS: The results of this study suggest that a reduction in CBF at the entorhinal cortex precedes tau deposition. Further work is needed to understand the mechanism underlying tau deposition in aging and disease.

Authors: Kapadia, A; Billimoria, K; Desai, P; Grist, JT; Heyn, C

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: XMLink
• Journal: Journal of Clinical Neurology
• Volume: 19
• Issue: 2
• Pages: 131-131
• Publication date: 2023-01-02
• DOI: 10.3988/jcn.2022.0088
• ISSN: 1738-6586
• Language: English
• Keywords: Cardiology; Nuclear medicine; Entorhinal cortex; Internal medicine; Neuroimaging; Alzheimer's Disease Neuroimaging Initiative; Temporal cortex; Cortex (anatomy); Medicine; Neuroscience; Alzheimer's disease; Pathology; Psychology; Cerebral blood flow; Disease; Hippocampus