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The antiviral efficacy of HIV-specific CD8⁺ T-cells to a conserved epitope is heavily dependent on the infecting HIV-1 isolate.

Abstract:

A major challenge to developing a successful HIV vaccine is the vast diversity of viral sequences, yet it is generally assumed that an epitope conserved between different strains will be recognised by responding T-cells. We examined whether an invariant HLA-B8 restricted Nef₉₀₋₉₇ epitope FL8 shared between five high titre viruses and eight recombinant vaccinia viruses expressing Nef from different viral isolates (clades A-H) could activate antiviral activity in FL8-specific cytotoxic T-lympho...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.ppat.1001341

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Institution:
University of Oxford
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Institution:
University of Oxford
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Institution:
University of Oxford
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Institution:
University of Oxford
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Institution:
University of Oxford
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Funding agency for:
Ranasinghe, SR
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS pathogens Journal website
Volume:
7
Issue:
5
Pages:
e1001341
Publication date:
2011-05-05
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
URN:
uuid:02031ac6-2927-40ed-bf60-a90b5c2f1dc8
Source identifiers:
9014
Local pid:
pubs:9014

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