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The effect of scale-free topology on the robustness and evolvability of genetic regulatory networks.

Abstract:

We investigate how scale-free (SF) and Erdos-Renyi (ER) topologies affect the interplay between evolvability and robustness of model gene regulatory networks with Boolean threshold dynamics. In agreement with Oikonomou and Cluzel (2006) we find that networks with SF(in) topologies, that is SF topology for incoming nodes and ER topology for outgoing nodes, are significantly more evolvable towards specific oscillatory targets than networks with ER topology for both incoming and outgoing nodes. ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.jtbi.2010.08.006

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Institution:
University of Oxford
Department:
Oxford, MPLS, Physics, Theoretical Physics
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Physics, Theoretical Physics
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Physics, Theoretical Physics
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Physical and Theoretical Chem
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Physics, Theoretical Physics
Publisher:
Elsevier Publisher's website
Journal:
Journal of theoretical biology Journal website
Volume:
267
Issue:
1
Pages:
48-61
Publication date:
2010-11-05
DOI:
EISSN:
1095-8541
ISSN:
0022-5193
URN:
uuid:01fdc971-5b67-4c18-a8b4-7d88daf0cb3f
Source identifiers:
66118
Local pid:
pubs:66118

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