We investigate how scale-free (SF) and Erdos-Renyi (ER) topologies affect the interplay between evolvability and robustness of model gene regulatory networks with Boolean threshold dynamics. In agreement with Oikonomou and Cluzel (2006) we find that networks with SF(in) topologies, that is SF topology for incoming nodes and ER topology for outgoing nodes, are significantly more evolvable towards specific oscillatory targets than networks with ER topology for both incoming and outgoing nodes. ...Expand abstract
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- Elsevier B.V.
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- Copyright 2010 Elsevier B.V. All rights reserved. NOTICE: this is the author's version of a work that was accepted for publication in CCurrent Opinion in Colloid and Interface Science. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in CCurrent Opinion in Colloid and Interface Science, Volume 11, Issue 1, April 2006, Pages 40-46, 10.1016/j.jtbi.2010.08.006
The effect of scale-free topology on the robustness and evolvability of genetic regulatory networks.
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