Effects of hypothyroidism on the structure and mechanical properties of bone in the ovine fetus.

Journal article

Thyroid hormones are important for normal bone growth and development in postnatal life. However, little is known about the role of thyroid hormones in the control of bone development in the fetus. Using computed tomography and mechanical testing, the structure and strength of metatarsal bones were measured in sheep fetuses in which thyroid hormone levels were altered by thyroidectomy or adrenalectomy. In intact fetuses, plasma concentrations of total calcium and the degradation products of C...

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Authors: Lanham, SA; Fowden, A; Roberts, C; Cooper, C; Oreffo, R

• Publication status: Published
• Journal: Journal of endocrinology
• Volume: 210
• Issue: 2
• Pages: 189-198
• Publication date: 2011-08-01
• DOI: 10.1530/joe-11-0138
• EISSN: 1479-6805
• ISSN: 0022-0795
• Language: English
• Keywords: Weight-Bearing; Calcium; Hypothyroidism; Sheep; Hydrocortisone; Thyroidectomy; Thyroid Hormones; Bone and Bones; Fetal Development; Animals; Bone Development