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Distinct requirements of positive and negative selection for selecting cell type and CD8 interaction.

Abstract:

We investigated the requirements of positive and negative selection in the thymus for CD8 interaction and the selecting cell type. Thymic epithelial cells are known to mediate positive selection, whereas thymocytes fail to do so. The reason for this failure could be either the low amount of MHC class I molecules on thymocytes or the lack of other properties required for positive selection. To address this question a CD2.Kb transgenic mouse was prepared in which the expression of the Kb gene i...

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Authors


Schönrich, G More by this author
Strauss, G More by this author
Müller, KP More by this author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
151
Issue:
8
Pages:
4098-4105
Publication date:
1993-10-05
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:01f76b96-9604-4d10-8ebc-01386cfd50db
Source identifiers:
483516
Local pid:
pubs:483516

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