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Assessing white matter ischemic damage in dementia patients by measurement of myelin proteins

Abstract:

White matter ischemia is difficult to quantify histologically. Myelin-associated glycoprotein (MAG) is highly susceptible to ischemia, being expressed only adaxonally, far from the oligodendrocyte cell body. Myelin-basic protein (MBP) and proteolipid protein (PLP) are expressed throughout the myelin sheath. We compared MAG, MBP, and PLP levels in parietal white matter homogenates from 17 vascular dementia (VaD), 49 Alzheimer's disease (AD), and 33 control brains, after assessing the post-mort...

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Publisher copy:
10.1038/jcbfm.2013.46

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
Journal:
Journal of Cerebral Blood Flow and Metabolism
Volume:
33
Issue:
7
Pages:
1050-1057
Publication date:
2013-07-05
DOI:
EISSN:
1559-7016
ISSN:
0271-678X
URN:
uuid:01f4b703-343b-46d3-8b41-7488727133ad
Source identifiers:
415353
Local pid:
pubs:415353

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