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Pharmacokinetic-pharmacodynamic evaluation of ceftazidime continuous infusion vs intermittent bolus injection in septicaemic melioidosis.

Abstract:

AIMS: Experimental studies have suggested that constant intravenous infusion would be preferable to conventional intermittent bolus administration of beta-lactam antibiotics for serious Gram-negative infections. Severe melioidosis (Burkholderia pseudomallei infection) carries a mortality over 40% despite treatment with high dose ceftazidime. The aim of this study was to measure the pharmacokinetic and pharmacodynamic effects of continuous infusion of ceftazidime vs intermittent bolus dosing ...

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Journal:
British journal of clinical pharmacology
Volume:
50
Issue:
2
Pages:
184-191
Publication date:
2000-08-05
DOI:
EISSN:
1365-2125
ISSN:
0306-5251
URN:
uuid:01dbe694-0995-4304-9ff9-908cb5da499d
Source identifiers:
95499
Local pid:
pubs:95499

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