BACKGROUND: Measures of impairment of oxygenation can be affected by the inspired oxygen fraction. METHODS: We used a mathematical model of an inhomogenous lung to predict the effect of increasing inspired oxygen concentration (FIO2) on: (1) venous admixture (Qva/Qt); (2) arterial oxygen partial pressure (PaO2); (3) the PaO2/FIO2 index of hypoxaemia; and (4) sulphur hexafluoride (SF6) retention (often taken to be true right-to-left shunt). This model predicts whether or not atelectasis will o...Expand abstract
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Variation of venous admixture, SF6 shunt, PaO2, and the PaO2/FIO2 ratio with FIO2.
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