Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal trafficking.

Journal article

Intracellular Ca(2+) signals constitute key elements in signal transduction. Of the three major Ca(2+) mobilizing messengers described, the most potent, nicotinic acid adenine dinucleotide phosphate (NAADP) is the least well understood in terms of its molecular targets [1]. Recently, we showed that heterologous expression of two-pore channel (TPC) proteins enhances NAADP-induced Ca(2+) release, whereas the NAADP response was abolished in pancreatic beta cells from Tpcn2 gene knockout mice [2]...

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Authors: Ruas, M; Rietdorf, K; Arredouani, A; Davis, L; Lloyd-Evans, E

• Publication status: Published
• Journal: Current biology : CB
• Volume: 20
• Issue: 8
• Pages: 703-709
• Publication date: 2010-04-01
• DOI: 10.1016/j.cub.2010.02.049
• EISSN: 1879-0445
• ISSN: 0960-9822
• Language: English
• Keywords: Humans; Calcium Signaling; Animals; Endosomes; Calcium; HEK293 Cells; NADP; Strongylocentrotus purpuratus; Calcium Channels; Lysosomes; Protein Isoforms