Journal article
Designing genetic feedback controllers
- Abstract:
- By incorporating feedback around systems we wish to manipulate, it is possible to improve their performance and robustness properties to meet pre-specified design objectives. For decades control engineers have been successfully implementing feedback controllers for complex mechanical and electrical systems such as aircraft and sports cars. Natural biological systems use feedback extensively for regulation and adaptation but apart from the most basic designs, there is no systematic framework for designing feedback controllers in Synthetic Biology. In this paper we describe how classical approaches from linear control theory can be used to close the loop. This includes the design of genetic circuits using feedback control and the presentation of a biological phase lag controller.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Access Document
- Files:
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(Preview, Accepted manuscript, pdf, 467.5KB, Terms of use)
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- Publisher copy:
- 10.1109/TBCAS.2015.2458435
Authors
+ Engineering and Physical Sciences Research Council
More from this funder
- Funding agency for:
- Harris, A
- Grant:
- EP/M002454/1
- Publisher:
- IEEE
- Journal:
- IEEE Transactions on Biomedical Circuits and Systems More from this journal
- Volume:
- 9
- Issue:
- 4
- Pages:
- 475-484
- Publication date:
- 2015-01-01
- DOI:
- EISSN:
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1940-9990
- ISSN:
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1932-4545
- Keywords:
- Pubs id:
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pubs:568467
- UUID:
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uuid:01be15a9-5ccb-4e7c-9788-d0903f3ba006
- Local pid:
-
pubs:568467
- Source identifiers:
-
568467
- Deposit date:
-
2015-10-21
- ARK identifier:
Terms of use
- Copyright holder:
- IEEE
- Copyright date:
- 2015
- Notes:
- Copyright © 2015 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
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