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Journal article

T cells discriminate between groups C1 and C2 HLA-C

Abstract:

Dimorphic amino acids at positions 77 and 80 delineate HLA-C allotypes into two groups, C1 and C2, which associate with disease through interactions with C1 and C2-specific natural killer cell receptors. How the C1/C2 dimorphism affects T cell recognition is unknown. Using HLA-C allotypes that differ only by the C1/C2-defining residues, we found that KRAS-G12D neoantigen-specific T cell receptors (TCRs) discriminated between C1 and C2 presenting the same KRAS-G12D peptides. Structural and fun...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/elife.75670

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
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Role:
Author
ORCID:
0000-0002-7793-3728
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Name:
Argonne National Laboratory
Publisher:
eLife Sciences Publications
Journal:
eLife More from this journal
Volume:
11
Article number:
e75670
Publication date:
2022-05-19
Acceptance date:
2022-05-15
DOI:
EISSN:
2050-084X
Pmid:
35587797
Language:
English
Keywords:
Pubs id:
1266456
Local pid:
pubs:1266456
Deposit date:
2022-11-11

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