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Frequency of germline hereditary non-polyposis colorectal cancer gene mutations in patients with multiple or early onset colorectal adenomas.

Abstract:

BACKGROUND: The hereditary non-polyposis colorectal cancer (HNPCC) syndrome is caused by germline mutations in mismatch repair genes and predisposes individuals to cancers of the colon and other specific sites. On theoretical grounds, it is expected that patients with HNPCC also develop more colorectal adenomas than the general population. In essence, if the mutation rate is raised owing to mutations at a mismatch repair locus, more mutations are expected at loci such as APC (adenomatous poly...

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Publisher copy:
10.1136/gut.41.2.235

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Journal:
Gut
Volume:
41
Issue:
2
Pages:
235-238
Publication date:
1997-08-05
DOI:
EISSN:
1468-3288
ISSN:
0017-5749
URN:
uuid:01b77d10-6f9e-43bc-9268-40b2758e8de8
Source identifiers:
72328
Local pid:
pubs:72328

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