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The 3' ends of human pre-snRNAs are produced by RNA polymerase II CTD-dependent RNA processing.

Abstract:

Proper 3' end formation of the human pre-snRNAs synthesized by pol II requires the cis-acting 3' box, although the precise function of this element has proved difficult to determine. In vivo, 3' end formation is tightly linked to transcription. However, we have now been able to obtain transcription-independent 3' box-dependent processing in vitro. This finally demonstrates that the 3' end of pre-snRNAs is produced by RNA processing rather than by termination of transcription. The phosphorylat...

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Publication status:
Published

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Publisher copy:
10.1093/emboj/cdg430

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
The EMBO journal
Volume:
22
Issue:
17
Pages:
4544-4554
Publication date:
2003-09-05
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:0194f6f3-7419-402e-b14f-f73e176e2a19
Source identifiers:
16739
Local pid:
pubs:16739

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