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Frequencies of peripheral blood myeloid cells in healthy Kenyan children with alpha+ thalassemia and the sickle cell trait.

Abstract:

The high frequencies of both alpha+ thalassemia and the sickle cell trait (hemoglobin AS [HbAS]) found in many tropical populations are thought to reflect selection pressure from Plasmodium falciparum malaria. For HbAS, but not for alpha+ thalassemia, protection appears to be mediated by the enhanced phagocytic clearance of ring-infected erythrocytes. We have investigated the genotype-specific distributions of peripheral blood leukocyte populations in two groups of children living on the coas...

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Publication status:
Published

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Authors


Cordery, DV More by this author
Macharia, A More by this author
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Journal:
The American journal of tropical medicine and hygiene
Volume:
74
Issue:
4
Pages:
578-584
Publication date:
2006-04-05
EISSN:
1476-1645
ISSN:
0002-9637
URN:
uuid:017ec1a7-617b-4469-9c59-9c785931e9fe
Source identifiers:
33442
Local pid:
pubs:33442

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