Review of treatment for late-life depression

Journal article

Depressive disorder in those over the age of 60 has many clinical similarities to depression in younger adults, but biological changes related to ageing may necessitate a different approach to treatment. We present an evidence-based review of treatment for late-life depression, focusing on pharmacological approaches, including monotherapy, combination and augmentation strategies. Selective serotonin reuptake inhibitors such as sertraline and citalopram are well tolerated, have the advantage of a favourable side-effect profile, and are good options for first-line treatment. Second-line treatment options include combination therapy with a second antidepressant, or treatment augmentation with an antipsychotic or lithium. We also consider evidence for non-pharmacological treatment strategies, including psychological therapy and neurostimulation. Finally, we summarise evidence for treatment of depression in patients in dementia.

Authors: Allan, C; Ebmeier, K

• Journal: Advances in Psychiatric Treatment
• Volume: 19
• Issue: 4
• Pages: 302-309
• Publication date: 2013-07-01
• DOI: 10.1192/apt.bp.112.010835
• EISSN: 1472-1481
• ISSN: 1355-5146
• Language: English