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Plasmodium falciparum pfmdr1 amplification, mefloquine resistance, and parasite fitness.

Abstract:

Mefloquine is widely used in combination with artemisinin derivatives for the treatment of falciparum malaria. Mefloquine resistance in Plasmodium falciparum has been related to increased copy numbers of multidrug-resistant gene 1 (pfmdr1). We studied the ex vivo dynamics of pfmdr1 gene amplification in culture-adapted P. falciparum in relation to mefloquine resistance and parasite fitness. A Thai P. falciparum isolate (isolate TM036) was assessed by the use of multiple genetic markers as a s...

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Publication status:
Published

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Publisher copy:
10.1128/aac.00241-08

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Role:
Author
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Journal:
Antimicrobial agents and chemotherapy
Volume:
53
Issue:
4
Pages:
1509-1515
Publication date:
2009-04-05
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
URN:
uuid:015c0327-ee96-401e-8ac5-5bfe5cdf9c68
Source identifiers:
28352
Local pid:
pubs:28352

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