Calcium activated chloride channel (CaCC) in GtoPdb v.2025.3

Journal article

Chloride channels activated by intracellular Ca2+ (CaCC) are widely expressed in excitable and non-excitable cells where they perform diverse functions [25]. CaCCs are activated by a rise in intracellular free Ca2+ concentration ([Ca2+]i), typically following activation of Gq protein coupled receptors (GqPCR). This section centres on CaCC channels encoded by the TMEM16A gene (HUGO gene nomenclature: Anoctamin 1). The TMEM16 family consists of 10 paralogs (TMEM16A-K; Anoctamin 1-10). The TMEM16A and TMEM16B genes (ANO1 and ANO2) encode for CaCCs, while the other members function as lipid scramblases or have combined scramblase and non-selective ion channel function [26, 46, 18, 1, 41]. TMEM16A has a broad tissue distribution and a variety of established cellular roles, while the main physiological role for TMEM16B identified thus far is in olfaction [31, 16]. Alternative splicing regulates the voltage- and Ca2+-dependence of TMEM16A and such post-transcriptional process may be tissue-specific and contribute to functional diversity [19]. TMEM16A is a potential drug target for a variety of conditions spanning from respiratory to vascular (see "Comments" section for further detail).

Authors: Danahay, H; Gosling, M; Tammaro, P

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Edinburgh University Library
• Journal: IUPHAR/BPS Guide to Pharmacology CITE
• Volume: 2025
• Issue: 3
• Publication date: 2025-09-10
• DOI: 10.2218/gtopdb/f130/2025.3
• EISSN: 2633-1020
• ISSN: 2633-1020
• Language: English